Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer
Identifieur interne : 004B35 ( Main/Exploration ); précédent : 004B34; suivant : 004B36Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer
Auteurs : Hanseul Yang [Corée du Sud] ; Chan Kim [Corée du Sud] ; Min-Ju Kim [Corée du Sud] ; Reto A. Schwendener [Suisse] ; Kari Alitalo [Finlande] ; Warren Heston [États-Unis] ; Injune Kim [Corée du Sud] ; Wun-Jae Kim [Corée du Sud] ; Gou Young Koh [Corée du Sud]Source :
- Molecular Cancer [ 1476-4598 ] ; 2011.
Abstract
Most bladder cancer patients experience lymphatic metastasis in the course of disease progression, yet the relationship between lymphangiogenesis and lymphatic metastasis is not well known. The aim of this study is to elucidate underlying mechanisms of how expanded lymphatic vessels and tumor microenvironment interacts each other and to find effective therapeutic options to inhibit lymphatic metastasis.
The orthotopic urinary bladder cancer (OUBC) model was generated by intravesical injection of MBT-2 cell lines. We investigated the angiogenesis, lymphangiogenesis, and CD11b+/CD68+ tumor-associated macrophages (TAM) by using immunofluorescence staining. OUBC displayed a profound lymphangiogenesis and massive infiltration of TAM in primary tumor and lymphatic metastasis in lymph nodes. TAM flocked near lymphatic vessels and express higher levels of VEGF-C/D than CD11b- cells. Because VEGFR-3 was highly expressed in lymphatic vascular endothelial cells, TAM could assist lymphangiogenesis by paracrine manner in bladder tumor. VEGFR-3 expressing adenovirus was administered to block VEGF-C/D signaling pathway and clodronate liposome was used to deplete TAM. The blockade of VEGF-C/D with soluble VEGF receptor-3 markedly inhibited lymphangiogenesis and lymphatic metastasis in OUBC. In addition, the depletion of TAM with clodronate liposome exerted similar effects on OUBC.
VEGF-C/D are the main factors of lymphangiogenesis and lymphatic metastasis in bladder cancer. Moreover, TAM plays an important role in these processes by producing VEGF-C/D. The inhibition of lymphangiogenesis could provide another therapeutic target to inhibit lymphatic metastasis and recurrence in patients with invasive bladder cancer.
Url:
DOI: 10.1186/1476-4598-10-36
PubMed: 21481239
PubMed Central: 3080348
Affiliations:
- Corée du Sud, Finlande, Suisse, États-Unis
- Canton de Zurich, Uusimaa
- Helsinki, Zurich
- Université d'Helsinki, Université de Zurich
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004210
- to stream Pmc, to step Curation: 004209
- to stream Pmc, to step Checkpoint: 002D34
- to stream Ncbi, to step Merge: 004266
- to stream Ncbi, to step Curation: 004266
- to stream Ncbi, to step Checkpoint: 004266
- to stream Main, to step Merge: 004B67
- to stream Main, to step Curation: 004B35
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer</title><author><name sortKey="Yang, Hanseul" sort="Yang, Hanseul" uniqKey="Yang H" first="Hanseul" last="Yang">Hanseul Yang</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Chan" sort="Kim, Chan" uniqKey="Kim C" first="Chan" last="Kim">Chan Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Min Ju" sort="Kim, Min Ju" uniqKey="Kim M" first="Min-Ju" last="Kim">Min-Ju Kim</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711</wicri:regionArea><wicri:noRegion>360-711</wicri:noRegion></affiliation></author><author><name sortKey="Schwendener, Reto A" sort="Schwendener, Reto A" uniqKey="Schwendener R" first="Reto A" last="Schwendener">Reto A. Schwendener</name><affiliation wicri:level="4"><nlm:aff id="I3">Laboratory of Liposome Research, Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Liposome Research, Institute of Molecular Cancer Research, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:aff id="I4">The Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>The Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Heston, Warren" sort="Heston, Warren" uniqKey="Heston W" first="Warren" last="Heston">Warren Heston</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Injune" sort="Kim, Injune" uniqKey="Kim I" first="Injune" last="Kim">Injune Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Wun Jae" sort="Kim, Wun Jae" uniqKey="Kim W" first="Wun-Jae" last="Kim">Wun-Jae Kim</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711</wicri:regionArea><wicri:noRegion>360-711</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21481239</idno><idno type="pmc">3080348</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080348</idno><idno type="RBID">PMC:3080348</idno><idno type="doi">10.1186/1476-4598-10-36</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">004210</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004210</idno><idno type="wicri:Area/Pmc/Curation">004209</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004209</idno><idno type="wicri:Area/Pmc/Checkpoint">002D34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002D34</idno><idno type="wicri:Area/Ncbi/Merge">004266</idno><idno type="wicri:Area/Ncbi/Curation">004266</idno><idno type="wicri:Area/Ncbi/Checkpoint">004266</idno><idno type="wicri:Area/Main/Merge">004B67</idno><idno type="wicri:Area/Main/Curation">004B35</idno><idno type="wicri:Area/Main/Exploration">004B35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer</title><author><name sortKey="Yang, Hanseul" sort="Yang, Hanseul" uniqKey="Yang H" first="Hanseul" last="Yang">Hanseul Yang</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Chan" sort="Kim, Chan" uniqKey="Kim C" first="Chan" last="Kim">Chan Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Min Ju" sort="Kim, Min Ju" uniqKey="Kim M" first="Min-Ju" last="Kim">Min-Ju Kim</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711</wicri:regionArea><wicri:noRegion>360-711</wicri:noRegion></affiliation></author><author><name sortKey="Schwendener, Reto A" sort="Schwendener, Reto A" uniqKey="Schwendener R" first="Reto A" last="Schwendener">Reto A. Schwendener</name><affiliation wicri:level="4"><nlm:aff id="I3">Laboratory of Liposome Research, Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Liposome Research, Institute of Molecular Cancer Research, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:aff id="I4">The Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>The Molecular/Cancer Biology Laboratory, Biomedicum Helsinki, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Heston, Warren" sort="Heston, Warren" uniqKey="Heston W" first="Warren" last="Heston">Warren Heston</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH</wicri:regionArea><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Injune" sort="Kim, Injune" uniqKey="Kim I" first="Injune" last="Kim">Injune Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Wun Jae" sort="Kim, Wun Jae" uniqKey="Kim W" first="Wun-Jae" last="Kim">Wun-Jae Kim</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Urology, College of Medicine, Institute for Tumor Research, Chungbuk National University, Cheongju, 360-711</wicri:regionArea><wicri:noRegion>360-711</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name><affiliation wicri:level="1"><nlm:aff id="I1">National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Research Laboratory of Vascular Biology and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701</wicri:regionArea><wicri:noRegion>305-701</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Cancer</title><idno type="eISSN">1476-4598</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Most bladder cancer patients experience lymphatic metastasis in the course of disease progression, yet the relationship between lymphangiogenesis and lymphatic metastasis is not well known. The aim of this study is to elucidate underlying mechanisms of how expanded lymphatic vessels and tumor microenvironment interacts each other and to find effective therapeutic options to inhibit lymphatic metastasis.</p></sec><sec><title>Results</title><p>The orthotopic urinary bladder cancer (OUBC) model was generated by intravesical injection of MBT-2 cell lines. We investigated the angiogenesis, lymphangiogenesis, and CD11b<sup>+</sup>/CD68<sup>+ </sup>tumor-associated macrophages (TAM) by using immunofluorescence staining. OUBC displayed a profound lymphangiogenesis and massive infiltration of TAM in primary tumor and lymphatic metastasis in lymph nodes. TAM flocked near lymphatic vessels and express higher levels of VEGF-C/D than CD11b<sup>- </sup>cells. Because VEGFR-3 was highly expressed in lymphatic vascular endothelial cells, TAM could assist lymphangiogenesis by paracrine manner in bladder tumor. VEGFR-3 expressing adenovirus was administered to block VEGF-C/D signaling pathway and clodronate liposome was used to deplete TAM. The blockade of VEGF-C/D with soluble VEGF receptor-3 markedly inhibited lymphangiogenesis and lymphatic metastasis in OUBC. In addition, the depletion of TAM with clodronate liposome exerted similar effects on OUBC.</p></sec><sec><title>Conclusion</title><p>VEGF-C/D are the main factors of lymphangiogenesis and lymphatic metastasis in bladder cancer. Moreover, TAM plays an important role in these processes by producing VEGF-C/D. The inhibition of lymphangiogenesis could provide another therapeutic target to inhibit lymphatic metastasis and recurrence in patients with invasive bladder cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hussain, S" uniqKey="Hussain S">S Hussain</name></author><author><name sortKey="James, N" uniqKey="James N">N James</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinagare, Ab" uniqKey="Shinagare A">AB Shinagare</name></author><author><name sortKey="Ramaiya, Nh" uniqKey="Ramaiya N">NH Ramaiya</name></author><author><name sortKey="Jagannathan, Jp" uniqKey="Jagannathan J">JP Jagannathan</name></author><author><name sortKey="Fennessy, Fm" uniqKey="Fennessy F">FM Fennessy</name></author><author><name sortKey="Taplin, Me" uniqKey="Taplin M">ME Taplin</name></author><author><name sortKey="Van Den Abbeele, Ad" uniqKey="Van Den Abbeele A">AD Van den Abbeele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bochner, Bh" uniqKey="Bochner B">BH Bochner</name></author><author><name sortKey="Cote, Rj" uniqKey="Cote R">RJ Cote</name></author><author><name sortKey="Weidner, N" uniqKey="Weidner N">N Weidner</name></author><author><name sortKey="Groshen, S" uniqKey="Groshen S">S Groshen</name></author><author><name sortKey="Chen, Sc" uniqKey="Chen S">SC Chen</name></author><author><name sortKey="Skinner, Dg" uniqKey="Skinner D">DG Skinner</name></author><author><name sortKey="Nichols, Pw" uniqKey="Nichols P">PW Nichols</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inoue, K" uniqKey="Inoue K">K Inoue</name></author><author><name sortKey="Slaton, Jw" uniqKey="Slaton J">JW Slaton</name></author><author><name sortKey="Karashima, T" uniqKey="Karashima T">T Karashima</name></author><author><name sortKey="Yoshikawa, C" uniqKey="Yoshikawa C">C Yoshikawa</name></author><author><name sortKey="Shuin, T" uniqKey="Shuin T">T Shuin</name></author><author><name sortKey="Sweeney, P" uniqKey="Sweeney P">P Sweeney</name></author><author><name sortKey="Millikan, R" uniqKey="Millikan R">R Millikan</name></author><author><name sortKey="Dinney, Cp" uniqKey="Dinney C">CP Dinney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, Mi" uniqKey="Fernandez M">MI Fernandez</name></author><author><name sortKey="Bolenz, C" uniqKey="Bolenz C">C Bolenz</name></author><author><name sortKey="Trojan, L" uniqKey="Trojan L">L Trojan</name></author><author><name sortKey="Steidler, A" uniqKey="Steidler A">A Steidler</name></author><author><name sortKey="Weiss, C" uniqKey="Weiss C">C Weiss</name></author><author><name sortKey="Alken, P" uniqKey="Alken P">P Alken</name></author><author><name sortKey="Grobholz, R" uniqKey="Grobholz R">R Grobholz</name></author><author><name sortKey="Michel, Ms" uniqKey="Michel M">MS Michel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saban, Mr" uniqKey="Saban M">MR Saban</name></author><author><name sortKey="Towner, R" uniqKey="Towner R">R Towner</name></author><author><name sortKey="Smith, N" uniqKey="Smith N">N Smith</name></author><author><name sortKey="Abbott, A" uniqKey="Abbott A">A Abbott</name></author><author><name sortKey="Neeman, M" uniqKey="Neeman M">M Neeman</name></author><author><name sortKey="Davis, Ca" uniqKey="Davis C">CA Davis</name></author><author><name sortKey="Simpson, C" uniqKey="Simpson C">C Simpson</name></author><author><name sortKey="Maier, J" uniqKey="Maier J">J Maier</name></author><author><name sortKey="Memet, S" uniqKey="Memet S">S Memet</name></author><author><name sortKey="Wu, Xr" uniqKey="Wu X">XR Wu</name></author><author><name sortKey="Saban, R" uniqKey="Saban R">R Saban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirakawa, S" uniqKey="Hirakawa S">S Hirakawa</name></author><author><name sortKey="Brown, Lf" uniqKey="Brown L">LF Brown</name></author><author><name sortKey="Kodama, S" uniqKey="Kodama S">S Kodama</name></author><author><name sortKey="Paavonen, K" uniqKey="Paavonen K">K Paavonen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacker, Sa" uniqKey="Stacker S">SA Stacker</name></author><author><name sortKey="Achen, Mg" uniqKey="Achen M">MG Achen</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Baldwin, Me" uniqKey="Baldwin M">ME Baldwin</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Kozaki, K" uniqKey="Kozaki K">K Kozaki</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Koshikawa, K" uniqKey="Koshikawa K">K Koshikawa</name></author><author><name sortKey="Yla Herttuala, S" uniqKey="Yla Herttuala S">S Yla-Herttuala</name></author><author><name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoshida, T" uniqKey="Hoshida T">T Hoshida</name></author><author><name sortKey="Isaka, N" uniqKey="Isaka N">N Isaka</name></author><author><name sortKey="Hagendoorn, J" uniqKey="Hagendoorn J">J Hagendoorn</name></author><author><name sortKey="Di Tomaso, E" uniqKey="Di Tomaso E">E di Tomaso</name></author><author><name sortKey="Chen, Yl" uniqKey="Chen Y">YL Chen</name></author><author><name sortKey="Pytowski, B" uniqKey="Pytowski B">B Pytowski</name></author><author><name sortKey="Fukumura, D" uniqKey="Fukumura D">D Fukumura</name></author><author><name sortKey="Padera, Tp" uniqKey="Padera T">TP Padera</name></author><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, J" uniqKey="Lin J">J Lin</name></author><author><name sortKey="Lalani, As" uniqKey="Lalani A">AS Lalani</name></author><author><name sortKey="Harding, Tc" uniqKey="Harding T">TC Harding</name></author><author><name sortKey="Gonzalez, M" uniqKey="Gonzalez M">M Gonzalez</name></author><author><name sortKey="Wu, Ww" uniqKey="Wu W">WW Wu</name></author><author><name sortKey="Luan, B" uniqKey="Luan B">B Luan</name></author><author><name sortKey="Tu, Gh" uniqKey="Tu G">GH Tu</name></author><author><name sortKey="Koprivnikar, K" uniqKey="Koprivnikar K">K Koprivnikar</name></author><author><name sortKey="Vanroey, Mj" uniqKey="Vanroey M">MJ VanRoey</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, N" uniqKey="Roberts N">N Roberts</name></author><author><name sortKey="Kloos, B" uniqKey="Kloos B">B Kloos</name></author><author><name sortKey="Cassella, M" uniqKey="Cassella M">M Cassella</name></author><author><name sortKey="Podgrabinska, S" uniqKey="Podgrabinska S">S Podgrabinska</name></author><author><name sortKey="Persaud, K" uniqKey="Persaud K">K Persaud</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Pytowski, B" uniqKey="Pytowski B">B Pytowski</name></author><author><name sortKey="Skobe, M" uniqKey="Skobe M">M Skobe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyata, Y" uniqKey="Miyata Y">Y Miyata</name></author><author><name sortKey="Kanda, S" uniqKey="Kanda S">S Kanda</name></author><author><name sortKey="Ohba, K" uniqKey="Ohba K">K Ohba</name></author><author><name sortKey="Nomata, K" uniqKey="Nomata K">K Nomata</name></author><author><name sortKey="Hayashida, Y" uniqKey="Hayashida Y">Y Hayashida</name></author><author><name sortKey="Eguchi, J" uniqKey="Eguchi J">J Eguchi</name></author><author><name sortKey="Hayashi, T" uniqKey="Hayashi T">T Hayashi</name></author><author><name sortKey="Kanetake, H" uniqKey="Kanetake H">H Kanetake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author><author><name sortKey="Morita, T" uniqKey="Morita T">T Morita</name></author><author><name sortKey="Tokue, A" uniqKey="Tokue A">A Tokue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murdoch, C" uniqKey="Murdoch C">C Murdoch</name></author><author><name sortKey="Muthana, M" uniqKey="Muthana M">M Muthana</name></author><author><name sortKey="Coffelt, Sb" uniqKey="Coffelt S">SB Coffelt</name></author><author><name sortKey="Lewis, Ce" uniqKey="Lewis C">CE Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lamagna, C" uniqKey="Lamagna C">C Lamagna</name></author><author><name sortKey="Aurrand Lions, M" uniqKey="Aurrand Lions M">M Aurrand-Lions</name></author><author><name sortKey="Imhof, Ba" uniqKey="Imhof B">BA Imhof</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Ce" uniqKey="Lewis C">CE Lewis</name></author><author><name sortKey="Pollard, Jw" uniqKey="Pollard J">JW Pollard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iwata, C" uniqKey="Iwata C">C Iwata</name></author><author><name sortKey="Kano, Mr" uniqKey="Kano M">MR Kano</name></author><author><name sortKey="Komuro, A" uniqKey="Komuro A">A Komuro</name></author><author><name sortKey="Oka, M" uniqKey="Oka M">M Oka</name></author><author><name sortKey="Kiyono, K" uniqKey="Kiyono K">K Kiyono</name></author><author><name sortKey="Johansson, E" uniqKey="Johansson E">E Johansson</name></author><author><name sortKey="Morishita, Y" uniqKey="Morishita Y">Y Morishita</name></author><author><name sortKey="Yashiro, M" uniqKey="Yashiro M">M Yashiro</name></author><author><name sortKey="Hirakawa, K" uniqKey="Hirakawa K">K Hirakawa</name></author><author><name sortKey="Kaminishi, M" uniqKey="Kaminishi M">M Kaminishi</name></author><author><name sortKey="Miyazono, K" uniqKey="Miyazono K">K Miyazono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeon, Bh" uniqKey="Jeon B">BH Jeon</name></author><author><name sortKey="Jang, C" uniqKey="Jang C">C Jang</name></author><author><name sortKey="Han, J" uniqKey="Han J">J Han</name></author><author><name sortKey="Kataru, Rp" uniqKey="Kataru R">RP Kataru</name></author><author><name sortKey="Piao, L" uniqKey="Piao L">L Piao</name></author><author><name sortKey="Jung, K" uniqKey="Jung K">K Jung</name></author><author><name sortKey="Cha, Hj" uniqKey="Cha H">HJ Cha</name></author><author><name sortKey="Schwendener, Ra" uniqKey="Schwendener R">RA Schwendener</name></author><author><name sortKey="Jang, Ky" uniqKey="Jang K">KY Jang</name></author><author><name sortKey="Kim, Ks" uniqKey="Kim K">KS Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoppmann, Sf" uniqKey="Schoppmann S">SF Schoppmann</name></author><author><name sortKey="Birner, P" uniqKey="Birner P">P Birner</name></author><author><name sortKey="Stockl, J" uniqKey="Stockl J">J Stockl</name></author><author><name sortKey="Kalt, R" uniqKey="Kalt R">R Kalt</name></author><author><name sortKey="Ullrich, R" uniqKey="Ullrich R">R Ullrich</name></author><author><name sortKey="Caucig, C" uniqKey="Caucig C">C Caucig</name></author><author><name sortKey="Kriehuber, E" uniqKey="Kriehuber E">E Kriehuber</name></author><author><name sortKey="Nagy, K" uniqKey="Nagy K">K Nagy</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horiguchi, Y" uniqKey="Horiguchi Y">Y Horiguchi</name></author><author><name sortKey="Larchian, Wa" uniqKey="Larchian W">WA Larchian</name></author><author><name sortKey="Kaplinsky, R" uniqKey="Kaplinsky R">R Kaplinsky</name></author><author><name sortKey="Fair, Wr" uniqKey="Fair W">WR Fair</name></author><author><name sortKey="Heston, Wd" uniqKey="Heston W">WD Heston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Egeblad, M" uniqKey="Egeblad M">M Egeblad</name></author><author><name sortKey="Karkkainen, M" uniqKey="Karkkainen M">M Karkkainen</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Yla Herttuala, S" uniqKey="Yla Herttuala S">S Yla-Herttuala</name></author><author><name sortKey="Jaattela, M" uniqKey="Jaattela M">M Jaattela</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Rajantie, I" uniqKey="Rajantie I">I Rajantie</name></author><author><name sortKey="Pajusola, K" uniqKey="Pajusola K">K Pajusola</name></author><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name></author><author><name sortKey="Yla Herttuala, S" uniqKey="Yla Herttuala S">S Yla-Herttuala</name></author><author><name sortKey="Harding, T" uniqKey="Harding T">T Harding</name></author><author><name sortKey="Jooss, K" uniqKey="Jooss K">K Jooss</name></author><author><name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeffers, Md" uniqKey="Jeffers M">MD Jeffers</name></author><author><name sortKey="O Dowd, Gm" uniqKey="O Dowd G">GM O'Dowd</name></author><author><name sortKey="Mulcahy, H" uniqKey="Mulcahy H">H Mulcahy</name></author><author><name sortKey="Stagg, M" uniqKey="Stagg M">M Stagg</name></author><author><name sortKey="O Donoghue, Dp" uniqKey="O Donoghue D">DP O'Donoghue</name></author><author><name sortKey="Toner, M" uniqKey="Toner M">M Toner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, L" uniqKey="Cheng L">L Cheng</name></author><author><name sortKey="Montironi, R" uniqKey="Montironi R">R Montironi</name></author><author><name sortKey="Davidson, D" uniqKey="Davidson D">D Davidson</name></author><author><name sortKey="Lopez Beltran, A" uniqKey="Lopez Beltran A">A Lopez-Beltran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Veikkola, T" uniqKey="Veikkola T">T Veikkola</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Kettunen, Mi" uniqKey="Kettunen M">MI Kettunen</name></author><author><name sortKey="Pulkkanen, Kj" uniqKey="Pulkkanen K">KJ Pulkkanen</name></author><author><name sortKey="Kauppinen, R" uniqKey="Kauppinen R">R Kauppinen</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Nishikawa, S" uniqKey="Nishikawa S">S Nishikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, Ch" uniqKey="Cho C">CH Cho</name></author><author><name sortKey="Koh, Yj" uniqKey="Koh Y">YJ Koh</name></author><author><name sortKey="Han, J" uniqKey="Han J">J Han</name></author><author><name sortKey="Sung, Hk" uniqKey="Sung H">HK Sung</name></author><author><name sortKey="Jong Lee, H" uniqKey="Jong Lee H">H Jong Lee</name></author><author><name sortKey="Morisada, T" uniqKey="Morisada T">T Morisada</name></author><author><name sortKey="Schwendener, Ra" uniqKey="Schwendener R">RA Schwendener</name></author><author><name sortKey="Brekken, Ra" uniqKey="Brekken R">RA Brekken</name></author><author><name sortKey="Kang, G" uniqKey="Kang G">G Kang</name></author><author><name sortKey="Oike, Y" uniqKey="Oike Y">Y Oike</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeisberger, Sm" uniqKey="Zeisberger S">SM Zeisberger</name></author><author><name sortKey="Odermatt, B" uniqKey="Odermatt B">B Odermatt</name></author><author><name sortKey="Marty, C" uniqKey="Marty C">C Marty</name></author><author><name sortKey="Zehnder Fjallman, Ah" uniqKey="Zehnder Fjallman A">AH Zehnder-Fjallman</name></author><author><name sortKey="Ballmer Hofer, K" uniqKey="Ballmer Hofer K">K Ballmer-Hofer</name></author><author><name sortKey="Schwendener, Ra" uniqKey="Schwendener R">RA Schwendener</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rinderknecht, M" uniqKey="Rinderknecht M">M Rinderknecht</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanada, T" uniqKey="Hanada T">T Hanada</name></author><author><name sortKey="Nakagawa, M" uniqKey="Nakagawa M">M Nakagawa</name></author><author><name sortKey="Emoto, A" uniqKey="Emoto A">A Emoto</name></author><author><name sortKey="Nomura, T" uniqKey="Nomura T">T Nomura</name></author><author><name sortKey="Nasu, N" uniqKey="Nasu N">N Nasu</name></author><author><name sortKey="Nomura, Y" uniqKey="Nomura Y">Y Nomura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, Bz" uniqKey="Qian B">BZ Qian</name></author><author><name sortKey="Pollard, Jw" uniqKey="Pollard J">JW Pollard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Zarkada, G" uniqKey="Zarkada G">G Zarkada</name></author><author><name sortKey="Wallgard, E" uniqKey="Wallgard E">E Wallgard</name></author><author><name sortKey="Murtomaki, A" uniqKey="Murtomaki A">A Murtomaki</name></author><author><name sortKey="Suchting, S" uniqKey="Suchting S">S Suchting</name></author><author><name sortKey="Wirzenius, M" uniqKey="Wirzenius M">M Wirzenius</name></author><author><name sortKey="Waltari, M" uniqKey="Waltari M">M Waltari</name></author><author><name sortKey="Hellstrom, M" uniqKey="Hellstrom M">M Hellstrom</name></author><author><name sortKey="Schomber, T" uniqKey="Schomber T">T Schomber</name></author><author><name sortKey="Peltonen, R" uniqKey="Peltonen R">R Peltonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tvorogov, D" uniqKey="Tvorogov D">D Tvorogov</name></author><author><name sortKey="Anisimov, A" uniqKey="Anisimov A">A Anisimov</name></author><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name></author><author><name sortKey="Leppanen, Vm" uniqKey="Leppanen V">VM Leppanen</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Laurinavicius, S" uniqKey="Laurinavicius S">S Laurinavicius</name></author><author><name sortKey="Holnthoner, W" uniqKey="Holnthoner W">W Holnthoner</name></author><author><name sortKey="Helotera, H" uniqKey="Helotera H">H Helotera</name></author><author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name></author><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flechon, A" uniqKey="Flechon A">A Flechon</name></author><author><name sortKey="Droz, J" uniqKey="Droz J">J Droz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>Finlande</li><li>Suisse</li><li>États-Unis</li></country><region><li>Canton de Zurich</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Zurich</li></settlement><orgName><li>Université d'Helsinki</li><li>Université de Zurich</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Yang, Hanseul" sort="Yang, Hanseul" uniqKey="Yang H" first="Hanseul" last="Yang">Hanseul Yang</name></noRegion><name sortKey="Kim, Chan" sort="Kim, Chan" uniqKey="Kim C" first="Chan" last="Kim">Chan Kim</name><name sortKey="Kim, Injune" sort="Kim, Injune" uniqKey="Kim I" first="Injune" last="Kim">Injune Kim</name><name sortKey="Kim, Min Ju" sort="Kim, Min Ju" uniqKey="Kim M" first="Min-Ju" last="Kim">Min-Ju Kim</name><name sortKey="Kim, Wun Jae" sort="Kim, Wun Jae" uniqKey="Kim W" first="Wun-Jae" last="Kim">Wun-Jae Kim</name><name sortKey="Koh, Gou Young" sort="Koh, Gou Young" uniqKey="Koh G" first="Gou Young" last="Koh">Gou Young Koh</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Schwendener, Reto A" sort="Schwendener, Reto A" uniqKey="Schwendener R" first="Reto A" last="Schwendener">Reto A. Schwendener</name></region></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country><country name="États-Unis"><noRegion><name sortKey="Heston, Warren" sort="Heston, Warren" uniqKey="Heston W" first="Warren" last="Heston">Warren Heston</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004B35 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004B35 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3080348
|texte= Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21481239" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |